This page gives general facts from the medicine label. It is not medical advice. Ask your doctor or pharmacist about your treatment.
People often ask how much weight they will lose each week on a GLP-1. The labels do not give a weekly number. They give the average change at the end of long studies. This page shows those numbers, and how to read your own weight.
What the studies on the label show
| Study | Medicine | Placebo |
|---|---|---|
| Wegovy 2.4 mg, 68 weeks, adults without diabetes | −14.9% | −2.4% |
| Zepbound 5 mg, 72 weeks, adults without diabetes | −15.0% | −3.1% |
| Zepbound 10 mg, 72 weeks, adults without diabetes | −19.5% | −3.1% |
| Zepbound 15 mg, 72 weeks, adults without diabetes | −20.9% | −3.1% |
In these studies, people also had a lower calorie diet and more physical activity. These are averages. Some people lost more, and some lost less.
What that means per week
If you divide the average by the number of weeks, you get about 0.2% to 0.3% of body weight each week. For a person of 100 kg, that is about 0.2 to 0.3 kg each week.
The table uses the results at the end. The labels also show that the average weight did not go down by the same amount each week. Use this number only to understand the studies, not as a goal.
Look at the trend, not the day
The study averages do not tell you what your own weight will do. One weight on one day says little. Look at the line over some weeks, and ask your doctor how to follow your progress.
When your weight stays the same
If your weight does not change for some weeks, write it down and talk to your doctor. Do not change your dose yourself. Your doctor can look at your dose, your food and your activity with you.